ParkinsonCanadaV1, Main, Exploration, bibRecord, 000489

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

Identifieur interne : 000489 ( Main/Exploration ); précédent : 000488; suivant : 000490

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

Auteurs : Thomas M. Durcan ; Edward A. Fon

Source :

Genes & Development [ 0890-9369 ] ; 2015.

RBID : PMC:4441056

English descriptors

KwdEn :
- Enzyme Activation, Humans, Mitochondria (enzymology), Mitochondria (genetics), Mitochondria (pathology), Mitochondrial Degradation (genetics), Mitochondrial Degradation (physiology), Parkinson Disease (enzymology), Parkinson Disease (pathology), Phosphorylation, Protein Kinases (genetics), Protein Kinases (metabolism), Protein Processing, Post-Translational, Ubiquitin-Protein Ligases (genetics), Ubiquitin-Protein Ligases (metabolism), Ubiquitination.
MESH :
- chemical , genetics : Protein Kinases, Ubiquitin-Protein Ligases.
- enzymology : Mitochondria, Parkinson Disease.
- genetics : Mitochondria, Mitochondrial Degradation.
- chemical , metabolism : Protein Kinases, Ubiquitin-Protein Ligases.
- pathology : Mitochondria, Parkinson Disease.
- physiology : Mitochondrial Degradation.
- Enzyme Activation, Humans, Phosphorylation, Protein Processing, Post-Translational, Ubiquitination.

Abstract

In this review, Durcan and Fon discuss how post-translational modifications are at the heart of how PARKIN and PINK1 function in mitochondrial quality control. They also ask how our current understanding of these proteins may impact the development of future therapies for Parkinson's disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441056

DOI: 10.1101/gad.262758.115
PubMed: 25995186
PubMed Central: 4441056

Affiliations:

Le document en format XML

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La maladie de Parkinson au Canada (serveur d'exploration)

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.